Therapeutic Gene Delivery from C.H.I.P.S.

Vector Targeting
for Therapeutic Gene Delivery

edited by David T. Curiel
and Joanne T. Douglas

Vector Targeting for Therapeutic Gene Delivery is an authoritative, clear presentation the most recent advances in target definition technology and the principles underlying the rational design of targeted vectors for gene therapy.

The first section of Vector Targeting for Therapeutic Gene Delivery focuses on transductional targeting strategies designed to achieve the selective delivery of the therapeutic gene by both nonviral and viral vectors, while the second section discusses transcriptional targeting, in which the therapeutic gene is placed under the control of transcriptional regulatory sequences that are activated in the disease cells, but not in normal cells, and therefore target expression selectively to the tumor cell.

Key Features:

  • Provides a theoretical framework for advanced vector design
  • Integrates all of the allied sciences relevant to the study of vector targeting
  • Includes an expert’s perspective on promising future therapeutic applications
  • Strategies that can be employed to define appropriate cellular targeting moieties
  • Strategies to monitor the extent of gene expression


  1. Transductionally Targeted Vectors-Nonviral

    1. Alternative Strategies for Targeted Delivery of Nucleic Acid-Liposome Complexes
    2. Targeted Gene Delivery via Lipidic Vectors
    3. Immunoliposomes: A Targeted Delivery Tool for Cancer Treatment
    4. Receptor-Directed Gene Delivery Using Molecular Conjugates

  2. Transductionally Targeted Vectors-Viral

    1. Pseudotyping of Adenoviral Vectors
    2. Targeting of Adenoviral Gene Therapy Vectors: The Flexibility of Chemical and Molecular Conjugation
    3. Genetic Targeting of Adenoviral Vectors
    4. Strategies to Alter the Tropism of Adenoviral Vectors via Genetic Capsid Modification
    5. Conjugate-Based Targeting of Adeno-Associated Virus Vectors
    6. Receptor Targeting of Adeno-Associated Virus Vectors
    7. Mechanisms of Retroviral Particle Maturation and Attachment
    8. Targeting Retroviral Vectors Using Molecular Bridges
    9. Genetic Targeting of Retroviral Vectors
    10. Genetic Engineering of Targeted Retroviral Vectors
    11. Targeting Measles Virus Entry
    12. Targeting of Poliovirus Replicons to Neurons in the Central Nervous System
    13. Generation of Safe, Targetable Sindbis Vectors that Have the Potential for Direct In Vivo Gene Therapy
    14. Redirecting the Tropism of HSV-1 for Gene Therapy Applications
    15. Engineering Targeted Bacteriophage as Evolvable Vectors for Therapeutic Gene Delivery
    16. Targeting Bacteriophage Vectors

  3. Transcriptional Targeting

    1. Tumor/Tissue Selective Promoters
    2. Promoter Optimization and Artificial Promoters for Transcriptional Targeting in Gene Therapy
    3. Physiological Targeting
    4. Clostridium-Mediated Transfer of Therapeutic Proteins to Solid Tumors

  4. Target Definition

    1. Selection of Peptides on Phage
    2. Antibody Phage Display Libraries for Use in Therapeutic Gene Targeting
    3. Single-Chain Fv Fragments from Phage Display Libraries
    4. Retroviral Particle Display for Complex Glycosylated and Disulfide-Bonded Protein Domains
    5. Cell Surface Display and Cytometric Screening for Protein Ligand Isolation and Engineering

  5. Monitoring of Targeting

    1. Monitoring Gene Therapy By Positron Emission Tomography


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    Vector Targeting
    for Therapeutic Gene Delivery

    edited by David T. Curiel, M.D.,
    and Joanne T. Douglas, Ph.D.

    710 pages • $195.95 + shipping
    Texas residents please add 6.75 % sales tax

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