Vector Targeting
for Therapeutic Gene Delivery
edited by David T. Curiel
and Joanne T. Douglas

Vector Targeting for Therapeutic Gene Delivery is an authoritative, clear presentation the most recent advances in target definition technology and the principles underlying the rational design of targeted vectors for gene therapy.

The first section of Vector Targeting for Therapeutic Gene Delivery focuses on transductional targeting strategies designed to achieve the selective delivery of the therapeutic gene by both nonviral and viral vectors, while the second section discusses transcriptional targeting, in which the therapeutic gene is placed under the control of transcriptional regulatory sequences that are activated in the disease cells, but not in normal cells, and therefore target expression selectively to the tumor cell.

Key Features:

• Provides a theoretical framework for advanced vector design
• Integrates all of the allied sciences relevant to the study of vector targeting
• Includes an expert’s perspective on promising future therapeutic applications
• Strategies that can be employed to define appropriate cellular targeting moieties
• Strategies to monitor the extent of gene expression

Contents:

1. Transductionally Targeted Vectors-Nonviral
   1. Alternative Strategies for Targeted Delivery of Nucleic Acid-Liposome Complexes
   2. Targeted Gene Delivery via Lipidic Vectors
   3. Immunoliposomes: A Targeted Delivery Tool for Cancer Treatment
   4. Receptor-Directed Gene Delivery Using Molecular Conjugates
   
   
2. Transductionally Targeted Vectors-Viral
   5. Pseudotyping of Adenoviral Vectors
   6. Targeting of Adenoviral Gene Therapy Vectors: The Flexibility of Chemical and Molecular Conjugation
   7. Genetic Targeting of Adenoviral Vectors
   8. Strategies to Alter the Tropism of Adenoviral Vectors via Genetic Capsid Modification
   9. Conjugate-Based Targeting of Adeno-Associated Virus Vectors
   10. Receptor Targeting of Adeno-Associated Virus Vectors
   11. Mechanisms of Retroviral Particle Maturation and Attachment
   12. Targeting Retroviral Vectors Using Molecular Bridges
   13. Genetic Targeting of Retroviral Vectors
   14. Genetic Engineering of Targeted Retroviral Vectors
   15. Targeting Measles Virus Entry
   16. Targeting of Poliovirus Replicons to Neurons in the Central Nervous System
   17. Generation of Safe, Targetable Sindbis Vectors that Have the Potential for Direct In Vivo Gene Therapy
   18. Redirecting the Tropism of HSV-1 for Gene Therapy Applications
   19. Engineering Targeted Bacteriophage as Evolvable Vectors for Therapeutic Gene Delivery
   20. Targeting Bacteriophage Vectors
   
   
3. Transcriptional Targeting
   21. Tumor/Tissue Selective Promoters
   22. Promoter Optimization and Artificial Promoters for Transcriptional Targeting in Gene Therapy
   23. Physiological Targeting
   24. Clostridium-Mediated Transfer of Therapeutic Proteins to Solid Tumors
   
   
4. Target Definition
   25. Selection of Peptides on Phage
   26. Antibody Phage Display Libraries for Use in Therapeutic Gene Targeting
   27. Single-Chain Fv Fragments from Phage Display Libraries
   28. Retroviral Particle Display for Complex Glycosylated and Disulfide-Bonded Protein Domains
   29. Cell Surface Display and Cytometric Screening for Protein Ligand Isolation and Engineering
   
   
5. Monitoring of Targeting
   30. Monitoring Gene Therapy By Positron Emission Tomography
   
   Index
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