Ventilator-Induced Lung Injury surveys current best practices in the prevention and management of ventilator-induced lung injury (VILI).

Features:

• Showcases the latest treatment regimens and applications with chapters by seasoned experts in the field
• Studies the many aspects of VILI generation and development
• Considers the physical and biological triggers of ventilator-induced lung injury
• Details the use of modern imaging technologies for an improved understanding of VILI mechanisms, progression, and treatment
• Describes methods to design clinical studies for the prevention of ventilator-associated lung injury

Contents

Introduction

• Ventilator-Induced Lung Injury: From Bench to Bedside and Back Again

Acute Manifestations of Vili

• Pathological Features of ARDS and VILI
• Imaging Alveolar Mechanics During VILI
• Response of Cellular Plasma Membrane to Mechanical Stress
• Passive and Active Changes in Microcascular Permeability During Lung Distension
• Meodynamic Interactions During VILI
• Gene Expression During VILI
• Lung Mechanics and VILI
• Effects of Acute Lung Distension on the Cytokine Network

Subacute VILI

• Inflammation Cascade During VILI
• Apoptosis in the Lung and Remote Organs During VILI
• Systemic Consequences of VILI/Evidence for Organ Failure Causation
• Interaction of VILI with Previous Lung Alterations
• Modulation of Lung Injury by Hypercapnia
• Potential Implications of Genomics in the Prevention and Treatment of VILI

Clinical Implications of VILI

• Lung Imaging of Ventilator-Associated Injury
• The Future of Lung Imaging of VILI/VALI
• Modulation of the Cytokine Network by Lung Protective Mechanical Ventilation Strategies
• Role of Tidal Volume and of Peep in the Reduction of Ventilator-Associated Lung Injury
• A Critical Review of Randomized Controls of Tidal Volume Reduction During ARDS

Prevention and Treatment of VILI

• The Importance of Protocol-Directed Management for Research on Lung Protective Ventilation
• How to Design Clinical Studies for the Prevention of Ventilator-Associated Lung Injury
• Potential Benefits and Risks of Partial Liquid Ventilation During Acute Lung Injury
• Prospects for Reduction of VILI with Surfactant
• Rationale for HFO Ventilations in Acute Lung Injury

Index

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