The long-awaited Sixth edition of Schalm’s Veterinary Hematology has been revised and reorganized to increase accessibility and cohesiveness of the text.

Topics are grouped within established disciplines in hematology, and outlines are now included at the beginning of each chapter. The book features new sections on Hematotoxicity and Quality Control and Laboratory Techniques, and includes expanded sections on Laboratory Animal Hematology, Species Specific Hematology, and Hematologic Neoplasia.

With in-depth coverage on all aspects of the field, this comprehensive reference is an essential purchase for veterinary clinical hematologists, internists, and students.

Contents

Section I. Hematopoiesis

1. Embryonic and Fetal Hematopoiesis
2. Structure of Bone Marrow
3. Stem Cell Biology
4. Cluster of Differentiation (CD) Antigens
5. The Hematopoietic System
6. Erythropoiesis
7. Granulopoiesis
8. Monocyte and Dendritic Cell Production and Distribution
9. Thrombopoiesis
10. Lymphopoiesis
11. Vasculogenesis/Endothelial Progenitor Cells

Section II. Hematotoxicity

12. Design and Methods Used for Preclinical Hematotoxicity Studies
13. Interpretation of Hematology Data in Preclinical Toxicological Studies
14. Preclinical Evaluation of Compound-Related Cytopenias
15. Preclinical Evaluation of Compound-Related Alterations in Hemostasis
16. Drug-induced Blood Cell Disorders
17. Myelonecrosis and Acute Inflammation
18. Chronic Inflammation and Secondary Myelofibrosis
19. Infectious Injury to Bone Marrow

Section III. Erythrocytes

20. Erythrocyte Structure and Function
21. Erythrocyte Biochemistry
22. Erythrokinetics and Erythrocyte Destruction
23. Erythrocyte Morphology
24. Laboratory and Clinical Diagnosis of Anemia
25. Polycythemia
26. Iron and Copper Deficiency and Disorder of Iron Metabolism
27. The Prophyrias and Prophyrinurias
28. Erythrocyte Enzyme Abnormalities
29. Erythrocyte Membrane Defects
30. Congenital Dyserythropoiesis
31. Anemias Caused by Rickettsia and Protozoa
32. Anemia Associated with Bacteria and Viral Infections
33. Immune-mediated Anemia in the Dog
34. Immune-mediated Anemia in the Cat
35. Immune-mediated Anemias in Ruminants and Horses
36. Anemias Associated with Oxidative Injury
37. Anemia of Inflammatory, Neoplastic, Renal, and Endocrine Diseases
38. Pure Red Cell Aplasia
39. Aplastic Anemia

Section IV. Leukocytes

40. Neutrophil Structure and Biochemistry
41. Neutrophil Distribution and Function
42. Neutrophil Function Disorders
43. Eosinophils and their Disorders
44. Basophils, Mast Cells and Their Disorders
45. Monocytes and Macrophages and Their Disorders
46. Interpretation of Ruminant Leukocyte Responses
47. Interpretation of Equine Leukocyte Responses
48. Interpretation of Canine Leukocyte Responses
49. Interpretation of Feline Leukocyte Responses
50. Determination and Interpretation of the Avian Leukogram
51. Biology of Lymphocytes and Plasma Cells
52. Structure, Function, and Disorders of Lymphoid Tissue
53. Disorders of the Spleen
54. Systemic Lupus Erythematosus
55. Feline Immunodeficiency Virus
56. T cell, Immunoglobulin, and Complement Immunodeficiency Disorders
57. Severe Combined Immunodeficiencies
58. Benign Lymphadenopathies

Section V. Hematologic Neoplasia

59. Cell Cycle Control in Hematopoietic Cells
60. Epidemiology of Hematopoietic Neoplasia
61. Genetics of Hematopoietic Neoplasia
62. Transforming Retroviruses
63. Bone Marrow-derived Sarcomas
64. Classification of Lymphoma and Leukemia
65. General Features of Leukemia and Lymphoma
66. Myelodysplastic Syndromes
67. Acute Myeloid Leukemia
68. Mast Cell Cancer
69. B-cell Tumors
70. Plasma Cell Tumors
71. Hodgkin’s Lymphoma
72. T cell Lymphoproliferative Diseases
73. Histiocytic Proliferative Diseases
74. Gene Therapy

Section VI. Platelets

75. Platelet Structure
76. Platelet Biochemistry Signal Transduction and Function
77. Platelet Kinetics and Laboratory Evaluation of Thrombocytopenia
78. Immune-mediated Thrombocytopenia
79. Non-immune-mediated Thrombocytopenia
80. Essential Thrombocythemia and Reactive Thrombocytosis
81. von Willebrand Disease
82. Inherited Intrinsic Platelet Disorders
83. Acquired Platelet Dysfunction

Section VII. Hemostasis

84. Overview of Hemostasis
85. Acquired Coagulopathies
86. Hereditary Coagulopathies
87. Thrombotic Disorders
88. Disseminated Intravascular Coagulation
89. Vascular Diseases
90. Treatment of Hemostatic Defects
91. Overview of Avian Hemostasis

Section VIII. Transfusion Medicine

92. Erythrocyte Antigens and Blood Groups
93. Granulocyte and Platelet Antigens
94. Principles of Canine and Feline Blood Collection, Processing, and Storage.
95. Red Blood Cell Transfusion in the Dog and Cat
96. Transfusion of Plasma Products
97. Platelet and Granulocyte Transfusion
98. Blood Transfusion in Large Animals
99. Blood Transfusion in Exotic Species
100. Transfusion Reactions
101. Major Histocompatability Complex Antigens
102. Hematopoietic Stem Cell Transplantation
103. Clinical Use of Hemopoietic Growth Factors

Section IX. Species Specific Hematology

104. Normal Hematology of the Dog
105. Normal Hematology of the Cat
106. Normal Hematology of the Horse
107. Normal Hematology of Cattle
108. Normal Hematology of Sheep, and Goats
109. Normal Hematology of the Pig
110. Hematology of Laboratory Animals
111. Hematology of Ferrets
112. Hematology of Guinea Pigs
113. Hematology of the Mongolian Gerbil
114. Hematology of the Syrian (Golden) Hamster
115. Hematology of Camelids
116. Hematology of Cervids
117. Hematology of Water Buffalo
118. Hematology of the American Bison
119. Hematology of Reindee
120. Hematology of Elephants
121. Hematology of Marine Mammals
122. Hematology of Chickens and Turkeys
123. Hematology of Psittacines
124. Hematology of Waterfowl and Raptors
125. Hematology of Ratites
126. Hematology of Fish
127. Hematology of Reptiles
128. Hematology of Elasmobranchs

Section X. Quality Control and Laboratory Techniques

129. Quality Control
130. Diagnostic Test Validation
131. Reference Intervals
132. Evaluation of Bone Marrow
133. Assays for Hematopoietic Precursor Cells
134. Radiolabeling and Scintigraphic Imaging of Platelets and Leukocytes
135. Automated Hematology Systems
136. Reticulocyte and Heinz Body Staining and Enumeration
137. Flow Cytometry
138. Laboratory Testing of Coagulation Disorders
139. Clinical Blood Typing and Crossmatching
140. Testing for Immune-mediated Hematologic Disease
141. Evaluation of Neutrophil Function
142. Evaluation of Platelet Function
143. Immunophenotyping and Determination of Clonality
144. Cytochemical Staining
145. Electrophoresis and Acute Phase Protein Measurement
146. Measurement of Serum Iron Concentration, TIBC, and Serum Ferritin Concentration
147. Molecular Techniques and Real time-PCR
148. Genetic Evaluation of Inherited and Acquired Hematologic Disease

Index

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