Vitamin D in Dermatology
edited by Knud Kragballe

Expands the classic view of vitamin D action to include important effects on cellular proliferation, differentiation, and the immune system and covers the application of vitamin D therapy to a range of skin diseases.This reference comprehensively covers the most recent findings on the biochemistry of vitamin D and its biologically active form, vitamin D ₃ (VD), in the skin detailing the extensive therapeutic benefits of VD and synthetic VD analogs, particularly in the treatment of psoriasis.

The only up-to-date monograph on dermatological vitamin D behavior from both molecular and clinical perspectives.

Written by over 35 world-renowned researchers and clinicians, Vitamin D in Dermatology features:

• highlights calcipotriol/calcipotriene, calcitriol, and tacalcitol and other antipsoriatic treatments
• illuminates the photochemistry and immunohistochemistry of vitamin D in the epidermis
• examines VD analogs that inhibit angiogenesis of skin cancers
• showcases vitamin D regulation of hair growth in vitro and against chemotherapy-induced alopecia
• evaluates the effectiveness of calcipotriol in combination with corticosteroids such as halobetasol
• explores VD or its analogs as a therapy for progressive systemic sclerosis and localized scleroderma
• assesses the calcemic action of vitamin D, relating cutaneous production of VD to its function in regulating bone mineral homeostasis
• and more!

Featuring over 40 color photographs,Vitamin D in Dermatology is a vitally important resource for clinical and research dermatologists, cosmetic scientists and technologists, pharmaceutical scientists, endocrinologists, pharmacists, pediatricians, and medical school students in these disciplines.

Contents

1. Mechanisms of Action and Metabolism
   • Molecular Mechanisms of Action of Vitamin D
   • The Vitamin D Receptor and Its Regulation in the Skin
   • Photobiology of Vitamin D₃
   • Metabolism of Vitamin D and Its Role in Calcium Metabolism
   
   
2. Target Cells and Actions in the Skin
   • Effect of Vitamin D on Keratinocyte Proliferation and Differentiation
   • Vitamin D and the Hair Follicle
   • Effect of Vitamin D on Melanocytes and Its Role in Melanogenesis
   • Modulation of Immunocytes by Vitamin D
   • Effect of Vitamin D on Langerhans Cells
   • Interaction of Vitamin D and Retinoids
   
   
3. Therapeutic Use in Psoriasis
   • Chemistry and Pharmacology of Calcipotriol
   • Monotherapy Including Long-Term Therapy with Calcipotriol
   • Combination Therapy: Calcipotriol and Corticosteroids
   • Calcipotriol/Calcipotriene (Dovonex/Daivonex) in Combination with Phototherapy
   • Combination of Calcipotriol with Systemic Antipsoriatic Treatments
   • Treatment of Scalp, Face, and Skin Folds with Calcipotriol
   • Skin Tolerability of Calcipotriol
   • Safety of Calcipotriol
   • Safety and Efficacy of Calcipotriol in Children
   • Clinical Use of Topical and Oral Calcitriol for Treating Psoriasis
   • Long-Term Therapy and Safety of Calcitriol
   • Chemistry and Pharmacology of Tacalcitol
   • Japanese Experience with Tacalcitol
   • European Experience with Tacalcitol
   
   
4. Therapeutic Use in Other Skin Diseases
   • Vitamin D Analogs in Ichthyosis and Other Disorders of Keratinization
   • Role of Vitamin D and Analogs in Local and Systemic Scleroderma
   • Experience with Vitamin D Analogs in Cutaneous Malignancies

Index

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