In Vivo MR Techniques in Drug Discovery and Development illustrates the use of MR techniques throughout the drug discovery and development process, from target identification and validation to clinical studies.

Features:

• Discusses applications for specific disease areas, emphasizing the advantages and limitations of the approaches
• Covers both preclinical animal research and clinical studies
• Includes an entire chapter devoted to high-throughput imaging of mice and another to the design of contrast agents for molecular imaging applications

Contents

1. The Drug Discovery and Development Process: A Brief Overview
2. The Drug Discovery and Development Process: Opportunities and Challenges for MR Techniques
3. Imaging as Biomarker for Decision-Making in Drug Development
4. Design of Contrast Agents for Molecular Imaging In Vivo
5. Rapid Phenotyping of Mice with MRI
6. Magnetic Resonance Imaging and Spectroscopy in Transgenic Mice Modeling Alzheimer's Disease
7. Imaging Alzheimer's Disease with MRI
8. MRI and MRS in Animal Models of Focal Cerebral Ischemia
9. MRI in Clinical Studies of Stroke
10. Pharmacologic Magnetic Resonance Imaging (phMRI)
11. Brain fMRI in Clinical Pharmacological Studies
12. Imaging Inflammatory Processes of the Brain: Multiple Sclerosis as an Example
13. Functional and Molecular Magnetic Resonance Imaging of Preclinical Cancer Models in Drug Discovery and Development
14. MR for Clinical Pharmacological Studies in Cancer
15. Molecular Imaging in Cancer Therapies of the Future
16. Cardiac MR Techniques Applied to Small Rodents
17. Cardiac MRI Techniques for Clinical Drug Trials
18. Lung MRI in Small Rodents as a Tool for the Evaluation of Drugs in Models of Airways Diseases
19. Clinical Applications of MRI in Respiratory Diseases
20. MR in Preclinical Diabetes and Obesity Drug Discovery
21. MR in Clinical Diabetes Research and Drug Trials
22. Rheumatoid and Osteoarthritis: Preclinical Applications of In Vivo MR
23. Rheumatoid and Osteoarthritis: Clinical Applications
24. In Vivo Magnetic Resonance Techniques in Transplantation Research
25. MR Imaging and the Development of Stem Cell-Based Therapies
26. MRI in Pharmaceutical Safety Assessment
27. In Vivo MR in Pharmaceutical Research: Essential or Nice to Have

Index

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