What's Wrong With My Mouse
Behavioral Phenotyping of Transgenic and Knockout Mice
Second edition
by Jacqueline N. Crawley

Turn to What’s Wrong with My Mouse? to discover the wealth of mouse behavioral tasks and to get the guidance you need to select the best methods and necessary controls.

Chapters are organized by behavioral domain in mutant mice, including:

• measurements of general health
• motor functions
• sensory abilities
• learning and memory
• feeding and drinking
• reproductive, social, emotional, and reward behaviors

Throughout the book, new behavioral tasks and new research discoveries have been added, bringing the Second Edition up to date with the latest science. In addition, this editionincludes two new chapters:

• "Neurodevelopment and Neurodegeneration" discusses mouse behavioral tasks relevant to neurodevelopmental diseases, such as mental retardation and autism, and to neurodegenerative diseases, such as Alzheimers, Parkinsons, Huntingtons, and amyotrophic lateral sclerosis
• "Putting It All Together" recommends strategies for optimizing a battery of behavioral phenotyping tests to address your specific hypotheses about gene functions

The use of behavioral testing equipment is illustrated with photographs, diagrams, and representative data. Examples of behavioral tasks successfully applied to transgenic and knockout mouse models are provided, as well as references to the primary literature and step-by-step methods protocols.

Contents

1. Designer Mice
2. Of Unicorns and Chimeras
3. General Health
4. Motor Functions
5. Sensory Abilities
6. Learning and Memory
7. Feeding and Drinking
8. Reproductive Behaviors
9. Social Behaviors
10. Emotional Behaviors
11. Reward
12. Neurodevelopment and Neurodegeneration
13. Putting It All Together
14. The Next Generation

Index

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